The TPP which communicates potential scenarios (best-worst case efficacy, AEs) or actual as seen in later clinical trial results informs many of the decisions and tactics that are needed by commercial teams: These include Early Phase Research with potential TPP scenarios can also be used n early phases to inform the strategy for pipeline innovations and assess those with more favorable forecasts. Business Development/Licensing of external assets where the TPP is used to assess interest in the product, potential use and an early estimate of market size. PreLaunch activities to help the Commercial team refine their and strategic plan for the product.